Gender-Affirming Care in South Carolina — No Referrals, No Gatekeeping

True U Clinic provides informed-consent hormone therapy and sexual health care for trans, nonbinary, and gender-diverse people across South Carolina. All care is virtual, confidential, and available as soon as tomorrow. Get Started Now

Yes, HRT Is Still Available in South Carolina

South Carolina has proposed or passed legislation targeting trans health care — but adults can still access gender-affirming hormone therapy. True U offers care that’s 100% legal, virtual, and affirming. No therapist letters, no insurance required, no gatekeeping — just care on your terms. Learn More About Our Process

Our Services

We serve patients across South Carolina with personalized, evidence-based care that respects your autonomy and identity.

Estrogen+ Therapy

We offer pills, patches, or injections — plus testosterone blockers and progesterone if desired. Your treatment plan is tailored to your needs.
Curious about starting estrogen? Talk with a provider

Testosterone Therapy

Due to current state telehealth regulations, we are not able to offer testosterone services in South Carolina at this time. We’re actively monitoring legal developments and remain committed to expanding access as soon as it becomes possible. Thank you for your understanding.

Prep & STI Testing

PrEP – A safer way to play

PrEP is an anti-viral treatment to prevent HIV in those who are at a higher risk of contracting HIV. Taken daily, PrEP medications can prevent up to 99% of HIV infections. Ask your True U provider if PrEP is right for you.

STI testing

Routine STI testing helps ensure your health and the health of your partners. We offer comprehensive STI testing including HIV, Gonorrhea, Chlamydia, Syphilis, Hepatitis B and C. We encourage you to talk with your True U provider to discuss your sexual health care and wellness!

  • "I have been obtaining my feminizing hormone replacement through True U for 6 months now. The service is very convenient and the care I received from Dr. Ashley has been caring and thorough. All I have to pay out of pocket is the visit costs, otherwise they allow me to use my insurance for the medications and labs. It is very cost effective for me. Thank you so much for offering this service to the community!"

    Lexy

  • "I cannot even begin to describe how grateful I am to the folx at this clinic. From day 1 I have been treated with immense compassion, kindness, and care. More importantly, I feel listened to! Beginning my journey, I felt so scared, nervous, and I honestly wanted to cry from stress. Working with Natalie at True U Clinic has been some of the best and most considerate treatment I have ever had from any medical clinic. I honestly and truly feel like a person and not treated as some random patient who's just a number. [...]Without their help, I wouldn't be on my journey to becoming me."

    Rachelle C.

  • "I've had an amazing experience with True U Clinic. My first appointment I had with Natalie I felt safe and comfortable and that I could be completely honest and be myself. [...] It felt so good to be able to be have a process that was caring and fast."

    Isaiah

  • "I love True U, I found them after some online searching for a quality transgender health care clinic and I couldn't be happier with my experience. Reasonable pricing, always quick and reliable with any questions you may have. [...] It's great I can use my insurance to pay for labs and hormones as well, it saves me a fortune! 10/10 would recommend to anyone seeking quality care."

    Jordan S.

  • "I am very thankful that True U Clinic is available to myself and others. Everyone I communicate with is polite and professional. I greatly appreciate the hard work they have done to work with my insurance company. They make transition much easier to handle by providing this service and I highly recommend them."

    Silver A.

  • "I am on my hormone therapy for 3 months now. My Dr. is very nice and listens to me on our telehealth sessions. If you have any questions True U answers you very quickly. They have e been very helpful with any concerns I had. I love True U Clinic it has helped me be the woman I am today."

    Cindy

Transparent, Affordable Pricing for South Carolina Residents

No subscriptions. No hidden costs. Just care you can count on.

Initial hormone therapy appointment

$259

Follow-up hormone therapy appointments

$195

Labs can be covered by insurance or are $99 through True U.
All expenses are eligible for HSA and FSA reimbursement

  • "I have been obtaining my feminizing hormone replacement through True U for 6 months now. The service is very convenient and the care I received from Dr. Ashley has been caring and thorough. All I have to pay out of pocket is the visit costs, otherwise they allow me to use my insurance for the medications and labs. It is very cost effective for me. Thank you so much for offering this service to the community!"

    Lexy

  • "I cannot even begin to describe how grateful I am to the folx at this clinic. From day 1 I have been treated with immense compassion, kindness, and care. More importantly, I feel listened to! Beginning my journey, I felt so scared, nervous, and I honestly wanted to cry from stress. Working with Natalie at True U Clinic has been some of the best and most considerate treatment I have ever had from any medical clinic. I honestly and truly feel like a person and not treated as some random patient who's just a number. [...]Without their help, I wouldn't be on my journey to becoming me."

    Rachelle C.

  • "I've had an amazing experience with True U Clinic. My first appointment I had with Natalie I felt safe and comfortable and that I could be completely honest and be myself. [...] It felt so good to be able to be have a process that was caring and fast."

    Isaiah

  • "I love True U, I found them after some online searching for a quality transgender health care clinic and I couldn't be happier with my experience. Reasonable pricing, always quick and reliable with any questions you may have. [...] It's great I can use my insurance to pay for labs and hormones as well, it saves me a fortune! 10/10 would recommend to anyone seeking quality care."

    Jordan S.

  • "I am very thankful that True U Clinic is available to myself and others. Everyone I communicate with is polite and professional. I greatly appreciate the hard work they have done to work with my insurance company. They make transition much easier to handle by providing this service and I highly recommend them."

    Silver A.

  • "I am on my hormone therapy for 3 months now. My Dr. is very nice and listens to me on our telehealth sessions. If you have any questions True U answers you very quickly. They have e been very helpful with any concerns I had. I love True U Clinic it has helped me be the woman I am today."

    Cindy

Online Medical Visits

Visits with True U Clinic are done from the convenience of your home over video and telephone platforms.

The visit is treated like any other doctor appointment, but virtually!

Blood work can be done from your house or locally at a lab close to you and the results are then sent to us. Once we start hormone therapy, we can have the medications shipped directly from the pharmacy to your home. Thus the process can be completed 100% from the privacy of your home!

South Carolina True U Hormone Therapy Provider

  • MSN, ANP, GNP

    Melanie has practiced since 2012. She is a graduate of the University of Texas. She practiced in multiple settings including community health and primary care. She enjoys delivering care to diverse cultures and populations. Melanie has strong LGBTQ family ties. She is very enthusiastic about delivering gender affirming hormone therapy and assisting individuals with their transitional journey.

Why South Carolinians Choose True U

More people across South Carolina are turning to True U for fast, affirming virtual care.

True U Clinic Other Solutions
No recurring membership – pay only for what you need, when you need it. Recurring membership, regardless of when you use it or need it.
Digital video appointments. Easy, private, secure In-person
Labs your way, on your own time Public labs, uncomfortable
Short appointment wait time – get started this week Long appointment wait times
Fastest response time – you are our priority! Long response times, if at all responsive
Easy and secure booking and appointment management portal No portal
Dedicated health care professional Rotating staff of health care professionals
Knowledgeable, supportive staff Staff may not be knowledgeable or supportive about trans-specific concerns or issues
100% Five-star reviews Mixed reviews

Frequently Asked Questions

  • We typically have appointments openings within ten days. You can easily, quickly, and confidentially schedule your appointment now!

  • Labs can be done in one of the three following ways:

    • Make an appointment at LabCorp: Have them drawn at a LabCorp near you. You can use insurance or self-pay through True U for $99.

    • Have the lab come to you: A mobile phlebotomist can draw the lab work directly from the privacy of your home! This service is $99 (+ $99 for self-pay labs).

    • Use a walk-in clinic. You may use insurance or self-pay. For self-pay we ship the lab supplies to you so you have them drawn at the walk-in clinic of your choice. The cost of self-pay labs (incl the lab kit) is $99.

  • We will send your prescription to the pharmacy of your choice. In addition, you may also use our mail-in pharmacy partner NewEra Pharmacy or our compounding pharmacy partner Empower Pharmacy.

  • Insurance may cover your medications. Out-of-pocket costs for medications are typically $20-60/month, depending on route of administration, types of medications, etc. If you self-pay for medications, we recommend using a GoodRx coupon for the lowest prices.

  • Consultation visits include STI testing, PrEP, and other hormone therapy needs outside of routine follow-up visits. The cost of consultation visits is $179/visit.

    • PrEP is an anti-viral treatment to prevent HIV in those who are at a higher risk of contracting HIV. Taken daily, PrEP medications can prevent up to 99% of HIV infections. Ask your True U provider if PrEP is right for you.

    • Routine STI testing helps ensure your health and the health of your partners. We offer comprehensive STI testing including HIV, Gonorrhea, Chlamydia, Syphilis, Hepatitis B and C. We encourage you to talk with your True U provider to discuss your sexual health care and wellness!

  • No, we do not charge monthly membership fees. At True U, you only pay for the care you receive.

  • In short, yes. At True U, we understand that transferring care can sometimes feel overwhelming. That’s why we’re committed to providing our clients with a seamless and stress-free process. Rather than requiring a two-visit start-up, we take the initiative to order labs before your first visit, allowing us to seamlessly continue your prescription from the very start. Our goal is to ensure your transition is as smooth as possible and to provide the high-quality care you deserve from day one.

  • We provide safe and medically supervised hormone therapy services in a safe, judgement-free, and secure setting utilizing modern HIPAA-compliant technology and the most up-to-date clinical practices.

  • Yes, as long as your provider is registered to practice in your state, you can choose your provider. You can sign up for your appointment (and choose your provider) by navigating to our online scheduling portal.

  • The bad news: We don’t take insurance. The good news: This means your information stays private, and you’ll never have to worry about claims being denied. Plus, we’ll provide you with a Superbill that you can submit to your insurance provider for potential reimbursement. And, to make things even easier, we accept HSA and FSA payments!

  • Our services are typically available for individuals over the age of 18. However, in certain states, we may be able to provide care for those under 18 with parental or guardian consent. Please call our office for more details on availability of care.